Therapeutic Evaluation of Swertia chirayita on Polypropylene Induced Lung Inflammation in Experimental Animal

• Nikita Sahebrao Wankhade Wankhade

  Vidyabharati college of Pharmacy, Amravati

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Microplastic pollution has emerged as a major environmental and public health concern due to its widespread presence in air, water, and food. Among various microplastics, polypropylene is extensively used in packaging materials, textiles, medical devices, and household products, leading to continuous human exposure through inhalation. Recent studies suggest that inhaled polypropylene particles can accumulate in lung tissues and trigger pulmonary inflammation, oxidative stress, and respiratory dysfunction. The present study was designed to evaluate the therapeutic potential of ethanolic extract of Swertia chirayita against polypropylene-induced lung inflammation in experimental animals. The study involved induction of lung inflammation using polypropylene particles followed by treatment with different doses of Swertia chirayita extract. Various inflammatory and biochemical parameters such as total cell count, neutrophil count, LDH activity, CINC-1, CINC-2, MPO levels, body weight, and histopathological changes were assessed to determine the protective effect of the plant extract. Results indicated that treatment with Swertia chirayita significantly reduced inflammatory markers and improved lung histopathology compared to the induced group. The anti-inflammatory and antioxidant properties of the phytoconstituents present in Swertia chirayita may contribute to its protective activity against polypropylene-induced pulmonary damage. Thus, the study suggests that Swertia chirayita could serve as a promising natural therapeutic agent for the management of microplastic-associated lung inflammation. 

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