Evaluation of the Therapeutic Potential of Rheum emodi  in Letrozole induced Polycystic Ovarian Disease in Female Wistar rats

• Ms.Vishakha Ranuji Kamble

  Agnihotri College of Pharmacy, Bapujiwadi, Ramnagar, Wardha, Maharashtra; 442001

  Author

Objective: To evaluate the therapeutic potential of Rheum emodi in the management of letrozole induced polycystic ovarian disease (PCOD) in the female Wistar rat model.

Methods: Letrozole (1mg/kg) was adminisetrd per orally (p.o) for a period of 21 days for induction of PCOD followed by dose of Clomiphene citrate (1mg/kg) with Rheum emodi (100 mg/kg, 200 mg/kg and 400 mg/kg. p.o) for 15 days using 1% CMC as vehicle.

Results: The administration of Letrozole led to abnormalcy in serum sex steroid profile, body weight, uterine weight and ovary weight. Rheum emodi was able to successfully exert its protective effect by restoring all the parameters to normal and disappearance of cysts in ovaries.

Conclusion: Rheum emodi showed beneficial effects in Letrozole induced PCOD in female Wistar rats. Its effect was comparable to that of Clomiphene citrate, most widely used treatment for ovulation induction in PCOD condition.

Copyright (c) 2026 International Journal of Research Welfare Society

This work is licensed under a Creative Commons Attribution 4.0 International License.

Article published in this journal are licensed under creative commons Attribution 4.0 International License ( CC BY 4.0)